| | Unique features of microfabricated chemical and biosensors make them extremely attractive in biomedical applications. Electrochemical microsensors can be utilized for local measurement of ion activities and/or various substrate concentrations in complex biological matrices. They allow depth-profile recordings in the living tissue and imaging of concentration distributions on surfaces. In our group, we adapt the existing semiconductor and microelectronics technologies to produce closely spaced sensor arrays on different substrates (e.g., flexible Kapton® or rigid ceramics). We develop in vitro analytical methods for extremely small sample volumes and/or sample concentrations. Our long-term goal is to make the strategic step from acute toward chronic measurements, i.e. toward implantable sensors, which are sterilizable, biocompatible, and do not need frequent calibration. The work is made in extensive collaborations with other universities. Other projects include the development of biosensors based on planar optical waveguide technology, biocompatibility of chronically implanted biosensors, and optical imaging to follow transport processes in sensor membranes. |
